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. 2018 Jan;110(1):44–51. doi: 10.5935/abc.20180008

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure.6 — Melatonin modulated expression of IP3R and SERCA2a via ERK1 pathway in reperfused rat hearts. In reperfused myocardium, expression of IP3R and SERCA2a were assessed by immunofluorescence staining (A) and quantitative analysis (B-C). The results showed that fluorescence intensity of IP3R was increased in I/R group more than in control group, but was lower in melatonin group compared with I/R group. On the contrary, melatonin increased expression of SERCA2a in reperfused myocardium. Both of the effects of melatonin on expression of IP3R and SERCA2a were inhibited by PD98059 (ERK1 inhibitor). bar = 30 µm. All values are presented as the mean ± SD. n = 5.*p < 0.05 vs. control group; Sp < 0.05 vs. I/R group; #p < 0.05 vs. I/R+Mel group. (Control: control group; I/R:I/R group; I/R+mel: I/R+ melatonin group; I/R+mel+PD: I/R+ melatonin+PD98059 group).