Table 2.
Association of single nucleotide polymorphisms (previously associated with venous thromboembolism in whites) with venous thromboembolism in African-Americans.
| Gene | SNP | Chromo- some |
Base Pair Position |
MAF | Minor Allele |
OR (95% CI) | P-value |
|---|---|---|---|---|---|---|---|
| F5 | rs4524 | 1 | 169511755 | 0.182 | C | 0.83(0.67,1.03) | 0.08 |
| F5 | rs6025 | 1 | 169519049 | 0.004 | T | 5.00(2.02,11.03) | 0.0002 |
| SERPINC1 | rs2227589 | 1 | 173886216 | 0.0605 | T | 0.81(0.58,1.14) | 0.22 |
| RGS7 | rs670659 | 1 | 241161775 | 0.2086 | T | 0.94(0.77,1.15) | 0.54 |
| PROC | rs1158867 | 2 | 128177377 | 0.2964 | T | 0.91(0.76,1.08) | 0.29 |
| PROS1 | rs121918472 | 3 | 93598150 | 1.00E-04 | G | NA | NA |
| KNG1 | rs710446 | 3 | 186459927 | 0.4964 | T | 1.14(0.98,1.34) | 0.10 |
| FGG | rs2066865 | 4 | 155525276 | 0.3028 | A | 1.08(0.92,1.27) | 0.33 |
| CYP4V2 | rs13146272 | 4 | 187120211 | 0.3986 | C | 0.91(0.77,1.07) | 0.24 |
| F11 | rs3822057 | 4 | 187188152 | 0.4354 | A | 1.01(0.87,1.18) | 0.86 |
| F11 | rs2036914 | 4 | 187192481 | 0.3589 | T | 0.95(0.81,1.12) | 0.55 |
| F11 | rs4253417 | 4 | 187199005 | 0.1545 | C | 1.06(0.85,1.31) | 0.63 |
| F11 | rs2289252 | 4 | 187207381 | 0.2569 | T | 1.05(0.88,1.25) | 0.59 |
| STAB2 | rs159381 | 5 | 58171932 | 0.3087 | A | 1.06(0.90,1.25) | 0.48 |
| HIVEP1 | rs169713 | 6 | 11920517 | 0.4249 | T | 1.03(0.88,1.2) | 0.71 |
| STXBP5 | rs1039084 | 6 | 147635413 | 0.4405 | G | 0.86(0.74,1.01) | 0.06 |
| ABO | rs8176747 | 9 | 136131315 | 0.3401 | G | 1.16(0.95,1.43) | 0.14 |
| ABO | rs8176746 | 9 | 136131322 | 0.1638 | T | 1.33(1.09,1.62) | 0.005 |
| ABO | rs8176719 | 9 | 136132908 | 0.3047 | TC | 1.30(1.11,1.53) | 0.002 |
| ABO | rs2519093 | 9 | 136141870 | 0.1122 | T | 1.04(0.82,1.32) | 0.76 |
| ABO | rs495828 | 9 | 136154867 | 0.1338 | T | 0.99(0.79,1.24) | 0.92 |
| TSPAN15 | rs78707713 | 10 | 71245276 | 0.0236 | C | 1.02(0.59,1.76) | 0.95 |
| HBB* | rs77121243 | 11 | 5248232 | 0.072 | A | 1.51(1.11,2.06) | 0.009 |
| F2 | rs1799963 | 11 | 46761055 | 0.0021 | A | 1.23(0.08,6.75) | 0.84 |
| VWF | rs1063856 | 12 | 6153534 | 0.4239 | T | 1.01(0.86,1.18) | 0.91 |
| STAB2 | rs4981021 | 12 | 104149999 | 0.1323 | T | 1.11(0.89,1.4) | 0.35 |
| TC2N | rs1884841 | 14 | 92309229 | 0.4827 | G | 0.95(0.81,1.11) | 0.54 |
| SLC44A2 | rs2288904 | 19 | 10742170 | 0.0603 | A | 1.04(0.75,1.45) | 0.82 |
| GP6 | rs1613662 | 19 | 55536595 | 0.2377 | G | 0.95(0.79,1.14) | 0.57 |
| PROCR | rs867186 | 20 | 33764554 | 0.0936 | G | 0.83(0.63,1.1) | 0.20 |
| PROCR | rs6087685 | 20 | 33777612 | 0.4053 | G | 1.16(0.98,1.38) | 0.09 |
Note: the result for HBB* rs77121243 (sickle cell risk variant) is from the analysis adjusted for site-platform combination, age, sex, stroke and principal components 1 and 2; the results for all the other SNPs are from the analysis adjusted for site-platform combination, age, sex, stroke, sickle cell risk variant (HBB rs77121243 T allele) and principal components 1 and 2. The SNPs are ordered by chromosome and base-pair position. CI, confidence interval; MAF, minor allele frequency; OR, odds ratio; SNP, single nucleotide polymorphism.