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. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2017 Oct 26;37(12):2260–2270. doi: 10.1161/ATVBAHA.117.310290

Table 2.

Kinetic Constants for the Plasma Clearance and Liver Accretion of nHDL-FC, PL, and Apo AI

	Plasma Decay Kinetics^*		Liver Uptake,

Plasma Analyte	k, min⁻¹	t_1/2, min	k, min⁻¹; uptake max, (%)	t_1/2, min
HDL-[³H]FC	0.68 ± 0.09	1.0 ± 0.09	0.91 ± 0.7 (25 ± 6)	0.77 ± 0.33
HDL-[¹⁴C]PL	0.46 ± 0.16	1.5 ± 0.4	0.46 ± 0.23 (12 ± 2)	1.5 ± 0.5
nHDL-[³H]FC	0.22 ± 0.12	3.2 ± 2.1	0.17 ± 0.06 (18 ± 3)	4.1 ± 1.1
nHDL-[¹⁴C]PL	0.52 ± 0.23	1.3 ± 0.7	0.71 ± 0.2 (11 ± 2)	1.4 ± 0.05
nHDL-[¹²⁵I]Apo AI^†	0.34 ± 0.29	2.1 ± 1.1	---	---
	(1.5 ± 0.32) × 10⁻³	460 ± 80

^*

From Figure 6 and Supplementary Figure VIII.

^†

apoAI kinetics were conducted on a longer time scale (Supplementary Figure VI) from which short and long components of the kinetics were calculated.