Table 4.
Predictors and Percent Native Kidney Recovery after Simultaneous Liver-Kidney Transplantation (SLKT) or Liver Transplantation Alone (LTA)
| Study | Type of Liver Transplant | Predictors | Number of Subjects | % Recovery | Definition of Native Kidney Recovery | Method used to Evaluate Native Kidney Recovery |
|---|---|---|---|---|---|---|
| Levitsky (2012)130 | SLKT | Renal ultrasound findings | 78 | 51% | > 20 ml/min | GFR measured by Tc-99m DTPA renal scan |
| 27% | > 30 ml/min | |||||
| 17% | > 40 ml/min | |||||
| Francis (2012)134 | SLKT | N/A | 13 | 38% | > 40% of total native kidney function | GFR measured by MAG3 renal scan |
| Nadim (2012)56 | LTA | Etiology of AKI based on RIFLE classification | 118 | ATN group 71% | < 50% increase in serum Cr | Serum Cr |
| Risk group 94% | ||||||
| HRS group 88% | ||||||
| Sharma (2013)132 | LTA | Diabetes, re-transplant, age, duration of dialysis | 2112 | 91% | Not on dialysis, not listed for kidney transplant, did not receive kidney transplant after LTA | Not applicable |
| Levitsky (2014)131 | LTA | Biomarkers (osteopontin, tissue inhibitor of metalloproteinase-1 diabetes, age | 16 test | 58% | Estimated GFR > 50 ml/min | GFR estimated by MDRD-4 equation |
| 46 validation | ||||||
| Wong (2015)133 | LTA | Duration of dialysis | 62 | 76% | HRS reversal defined as serum Cr < 1.5 mg/dL | Serum Cr |
| Laskey (2016)129 | LTA | Liver graft warm ischemia time | 40 | 65% | Not on dialysis, not listed for kidney transplant, serum Cr < 2 mg/dL after LTA | Serum Cr |
DTPA=Diethylene triamine pentaacetic acid; MAG3=mercaptoacetyltriglycine