Table 3.
Cox regression* adjusted for within-pair difference. HR of mortality according to RHR. Time extends from time of RHR measurement† to death or 1 June 2015
| Risk factor | n | Events | Crude HR | Adj‡ HR | Adj§ HR | Adj¶ HR |
|---|---|---|---|---|---|---|
| Mortality | ||||||
| 40–50 | 64 | 20 | 0.94 (0.60 to 1.48) | 0.94 (0.60 to 1.48) | 0.89 (0.56 to 1.42) | 0.76 (0.44 to 1.31) |
| 51–60 | 548 | 160 | 1.23 (1.03 to 1.48) | 1.22 (1.02 to 1.46) | 1.21 (1.01 to1.46) | 1.35 (1.10 to 1.66) |
| 61–70 | 1512 | 419 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) |
| 71–80 | 1444 | 456 | 1.10 (0.97 to 1.26) | 1.18 (1.04 to 1.35) | 1.18 (1.03 to1.35) | 1.13 (0.97 to 1.32) |
| 81–90 | 475 | 178 | 1.71 (1.43 to 2.03) | 1.78 (1.49 to 2.12) | 1.77 (1.49 to2.12) | 1.61 (1.31 to 1.98) |
| 90–120 | 239 | 101 | 1.64 (1.32 to 2.04) | 1.86 (1.50 to 2.31) | 1.85 (1.48 to 2.30) | 1.56 (1.21 to 2.03) |
| CVD death | ||||||
| 40–50 | 64 | 5 | 1.17 (0.47 to 2.88) | 1.13 (0.45 to 2.79) | 1.13 (0.46 to 2.81) | 1.10 (0.39 to 3.11) |
| 51–60 | 548 | 37 | 1.54 (1.04 to 2.27) | 1.53 (1.03 to 2.26) | 1.54 (1.04 to 2.28) | 1.65 (1.05 to 2.60) |
| 61–70 | 1512 | 80 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) |
| 71–80 | 1444 | 98 | 1.22 (0.91 to 1.64) | 1.27 (0.94 to 1.71) | 1.28 (0.95 to 1.73) | 1.22 (0.87 to 1.72) |
| 81–90 | 475 | 39 | 2.00 (1.37 to 2.94) | 2.07 (1.41 to 3.03) | 2.03 (1.38 to 2.99) | 1.40 (0.86to 2.27) |
| 90–120 | 239 | 25 | 2.14 (1.36 to 3.35) | 2.30 (1.46 to 3.61) | 2.32 (1.48 to 3.65) | 2.19 (1.30 to 3.67) |
*
Stratified Cox model with pair-specific baseline hazard functions,17
†
Adjustments were made for all covariates at time of interview,
‡
Adjusted for gender and age at interview,
§
Adjusted for gender, age at interview and BMI,
¶
Adjusted for gender, age at interview, BMI, FEV1, diabetes, hypertension, smoking, physical activity and zygosity.
BMI, body mass index; FEV1, forced expiratory volume in 1 s; RHR, resting heart rate.