Table 1. Multivariate Cox Regression Analysis for Overall Survival.
| Factors | Discovery Data Set | Validation Data Set | ||
|---|---|---|---|---|
| HR (95% Cl) | P Value | HR (95% Cl) | P Value | |
| Age, modeled as a continuous variable | 1.00 (0.99-1.02) | .67 | 1.02 (1.01-1.04) | .005a |
| Sex | ||||
| Women | 1 [Reference] | .11 | 1 [Reference] | .15 |
| Men | 0.67 (0.41-1.09) | 0.76 (0.52-1.11) | ||
| Differentiation | ||||
| Differentiated | 1 [Reference] | .80 | 1 [Reference] | .92 |
| Undifferentiated | 1.08 (0.62-1.87) | 1.02 (0.65-1.61) | ||
| Lauren classification | ||||
| Intestinal type | 1 [Reference] | .83 | 1 [Reference] | .40 |
| Diffuse type | 0.95 (0.58-1.54) | 1.17 (0.81-1.69) | ||
| TNM stage according to increase in stage | 2.76 (1.88-4.04) | <.001a | 2.58 (1.91-3.49) | <.001a |
| MGMT expression | ||||
| Negative | 1 [Reference] | .03a | 1 [Reference] | .04a |
| Positive | 0.61 (0.40-0.96) | 0.68 (0.48-0.98) | ||
Abbreviations: HR, hazard ratio; MGMT, O6-methylguanine-DNA methyltransferase.
a
Shows statistical significance.