. 2017 Sep 13;152(11):e173120. doi: 10.1001/jamasurg.2017.3120

Table 2. Treatment Interaction With MGMT Expression for Overall Survival^a.

MGMT Expression	Patients With Stage II Disease (n = 104)				Patients With Stage III Disease (n = 229)
MGMT Expression	With ACT	Without ACT	With ACT vs Without ACT, HR (95% CI)	P Value for Interaction	With ACT	Without ACT	With ACT vs Without ACT, HR (95% CI)	P Value for Interaction
Negative	18	11	0.71 (0.27-1.92)	.007^b	70	23	0.35 (0.21-0.59)	.08
Positive	48	27	0.35 (0.13-0.95)	.007^b	112	24	0.28 (0.17-0.46)	.08

Abbreviations: ACT, adjuvant chemotherapy; HR, hazard ratio; MGMT, O⁶-methylguanine-DNA methyltransferase.

^{^a}

Estimated from a Cox proportional hazards model on the combined data set of 333 patients with stage II or III gastric cancer.

^{^b}

Shows statistical significance.

Table 2. Treatment Interaction With MGMT Expression for Overall Survivala.