Table 4. Clinical Outcomes and Intraoperative Serious Events.
| Variable | Overall (N = 390) |
Intervention (n = 189) |
Placebo (n = 201) |
P Value |
|---|---|---|---|---|
| Delirium, No. (%) | ||||
| Postoperative delirium | 46 (11.8) | 23 (12.2) | 23 (11.4) | .94 |
| PACU delirium | 14 (3.6) | 6 (3.2) | 8 (4.0) | |
| Both | 9 (2.3) | 5 (2.6) | 4 (2.0) | |
| None | 321 (82.3) | 155 (82.0) | 166 (82.6) | |
| Intraoperative bradycardia, No. (%) | ||||
| Requiring treatment | 55 (14.1) | 35 (18.5) | 20 (10.0) | .06 |
| Requiring interruption of the drug | 4 (1.0) | 2 (1.1) | 2 (1.0) | |
| Resolved spontaneously | 87 (22.3) | 45 (23.8) | 42 (20.9) | |
| Did not occur | 244 (62.6) | 107 (56.6) | 137 (68.2) | |
| Intraoperative hypotension, No. (%) | ||||
| Requiring treatment | 150 (38.5) | 81 (42.9) | 69 (34.3) | .36 |
| Requiring interruption of the drug | 8 (2.1) | 3 (1.6) | 5 (2.5) | |
| Resolved spontaneously | 39 (10.0) | 18 (9.5) | 21 (10.4) | |
| Did not occur | 193 (49.5) | 87 (46.0) | 106 (52.7) | |
| Intraoperative hypertension, No. (%) | ||||
| Requiring treatment | 62 (15.9) | 26 (13.8) | 36 (17.9) | .10 |
| Requiring interruption of the drug | 1 (0.3) | 0 | 1 (0.5) | |
| Resolved spontaneously | 47 (12.1) | 17 (9.0) | 30 (14.9) | |
| Did not occur | 280 (71.8) | 146 (77.2) | 134 (66.7) | |
| Death, No. (%) | 4 (1.0) | 1 (0.5) | 3 (1.5) | .35 |
| Serious adverse event, No. (%) | 22 (5.6) | 13 (6.9) | 9 (4.5) | .30 |
| Length of stay, median (IQR), d | 4.0 (3.0-6.0) | 4.0 (3.0-6.0) | 4.0 (3.0-6.0) | .27 |
Abbreviations: IQR, interquartile range; PACU, postanesthesia care unit.