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. Author manuscript; available in PMC: 2019 Mar 2.

Published in final edited form as: Virus Res. 2018 Jan 31;247:26–33. doi: 10.1016/j.virusres.2018.01.010

Table 4.

Effects of the siRNA treatment for PDI1, PDIA3, PDIA4 or Grp78 on the replication of group A and B influenza viruses in MDCK and A549 cells.

siRNA	Virus titer (Log₁₀ TCID₅₀/ml)
	MDCK			A549
	A/WS/33	A/swine/OH/2007	B/Lee/40	A/WS/33	A/swine/OH/2007	B/Lee/40
Mock (water)	8.3 (0.2)	7.3 (0.5)	8.7 (0.5)	5.3 (0.2)	4.6 (0.3)	5.9 (0.5)
PDI1 (P4HB, PDIA1)	4.1 (0.6)^*	4.7 (0.5)^*	5.0 (0.3)^*	3.2 (0.4)^*	3.5 (0.3)^*	4.4 (0.3)^*
PDIA3 (Erp57)	4.8 (0.6)^*	5.1 (0.6)^*	5.1 (0.7)^*	3.6 (0.5)^*	3.8 (0.3)^*	4.9 (0.2)^*
PDIA4 (Erp72)	3.5 (0.4)^*	3.7 (0.4)^*	4.5 (0.4)^*	3.2 (0.3)^*	2.9 (0.3)^*	4.1 (0.5)^*
Grp78 (BiP)	5.2 (0.4)^*	5.1 (0.4)^*	5.5 (0.5)^*	4.2 (0.5)^*	3.8 (0.5)^*	4.8 (0.3)^*
Irrelevant siRNA	8.6 (0.5)	7.5 (0.6)	8.5 (0.4)	5.3 (0.5)	4.7 (0.4)	6.1 (0.5)

^*

Statistically significant differences from the mock (p < 0.05). The numbers in parentheses are standard deviations of the means.