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Preparation of MDM2 binding peptide analog 11 bearing a phenyl carbamate. (a) X-ray crystal structure of MDM2-pDIQ complex (PDB ID: 3JZS) and design of pDIQ analog 10 for cysteine arylation. (b) The palladium-mediated cysteine arylation of 10. LC-MS analysis showed full conversion of 10 to form the desired product 11.
