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Protein-selective intermolecular crosslinking between a peptide and an interacting protein. (a) Intermolecular crosslinking of MDM2 (9) with the arylated pDIQ binder analog 11. The deconvoluted mass spectra for the whole protein peak from LC-MS analysis of the crude reaction mixture showed no multiple crosslinked products. (b) Protein-selective intermolecular crosslinking of MDM2 (9) in a protein mixture. Only MDM2 (9) was modified as indicated by the LC-MS analysis.
