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. Author manuscript; available in PMC: 2019 Feb 28.
Published in final edited form as: Chem Rev. 2018 Jan 10;118(4):1691–1741. doi: 10.1021/acs.chemrev.7b00305

Figure 10.

Figure 10

Acid activation and proton conductance of the influenza A M2 protein. (a) Structure in the closed state (PDB entry 2L0J). (left) Structure embedded in the membrane; concentration of basic residues in the inner leaflet is in line with the positive-inside rule. (right) His37 and other key pore-lining residues. Reprinted with permission from ref 362. Copyright 2010 American Association for the Advancement of Science. (b) External proton attack of a His37 imidazole–imidazolium hydrogen-bonded dimer may end with a proton returned to the same aqueous compartment (futile cycle) or transferred to the internally exposed compartment (conductance cycle). Reprinted with permission from ref 361. Copyright 2015 Elsevier.