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. Author manuscript; available in PMC: 2019 Feb 28.
Published in final edited form as: Chem Rev. 2018 Jan 10;118(4):1691–1741. doi: 10.1021/acs.chemrev.7b00305

Figure 11.

Figure 11

Temperature dependence of the unfolding free energy −ΔGfold. The melting temperature increases with increasing −ΔGfold(Ts), decreasing ΔCp, and increasing Ts, as illustrated by the green, blue, and red curves, respectively.