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. Author manuscript; available in PMC: 2019 Feb 28.
Published in final edited form as: Chem Rev. 2018 Jan 10;118(4):1691–1741. doi: 10.1021/acs.chemrev.7b00305

Figure 2.

Figure 2

(a) Solvation energy (purple curve) of a unit charge and interaction energy (green curve) between two unit charges inside a spherical protein. The two charges have opposite signs and are at the same radial distance (r) with a distance of 4 Å between them. (b) Effect of salt ions on the electrostatic energy of a charge distribution in a spherical protein. There are 46 charges of ±1, randomly distributed at 2 Å below the protein surface. The common parameters are εp = 4, εs = 80, and R = 16 Å. For (a), κ = 0; for (b), R′ = 18 Å and κ = I1/2/3.04 Å−1. Energies are in units of kcal/mol.