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. Author manuscript; available in PMC: 2019 Feb 28.
Published in final edited form as: Chem Rev. 2018 Jan 10;118(4):1691–1741. doi: 10.1021/acs.chemrev.7b00305

Figure 3.

Figure 3

(a) Dehydration cost for bringing a single ion to the surface of a spherical protein in the presence of 1 M 1:1 salt (parameters are as given in Figure 2b; kBT = 0.59 kcal/mol). r is the final radial distance of the ion. (b) Ionic strength dependences of the dehydration cost WK for an equilibrium distribution of ions around the protein and the protein solubility. The latter is calculated from the WK term shown and the ΔGDH term shown in Figure 2b. (c) Dependence of hemoglobin solubility on concentrations of various salts; curves are fits to an empirical formula that has the same form as eq 12 but with simplified expressions for ΔGDH and WK. Panel c reprinted with permission from ref 70. Copyright 1932 American Society for Biochemistry and Molecular Biology.