Table 2.

The ten top variants from the single-variant analysis with minor allele frequency ≥ 0.5% in HyperGEN (N=1,934)

Left ventricular traits	SNP	Chr	Position	Gene	SNP function	MAF	Beta	p-value
LAD	rs45470697	5	149212624	PPARGC1B	R330W	0.06	−0.04	5.6*10−7
LAD	rs45519432	5	149212802	PPARGC1B	S389Y	0.06	−0.04	5.7*10−7
E/A ratio	rs8176919	16	3706697	DNASE1	G127R	0.06	0.08	4.7*10−6
E/A ratio	rs41277210	1	216144049	USH2A	R2292H	0.01	0.23	8.4*10−6
LVIDD	rs35892492	20	62333521	ARFRP1	W105R	0.01	0.09	9.8*10−6
RWT	rs769929111	1	55075452	FAM151A	A416V	0.23	0.03	1.3*10−5
FS	rs11555566	20	43255220	ADA	K80R	0.07	1.54	1.4*10−5
FS	rs36009281	5	70798541	BDP1	K722E	0.01	−3.58	1.7*10−5
E/A ratio	rs1801270	6	36651971	CDKN1A	S31R	0.27	0.04	2.1*10−5
E/A ratio	rs9911502	17	73518203	TSEN54	K347N	0.20	0.04	3.0*10−5

^*The models were adjusted for age, gender, center, body mass index and first 10 principal components. LAD: left atrial dimension. E/A ratio, the ratio of left ventricular transmitral early velocity to late/atrial velocity. LVIDD, left ventricular internal dimension-diastole. RWT, relative wall thickness. FS, fractional shortening. LAD was square-rooted. E/A ratio, LVIDD, and RWT were natural log-transformed. MAF: minor allele frequency.