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Comparative analysis of cell death (%) of monolayer and spheroid ACC cells analyzed by MTS assay
| Monolayer | Spheroids | |||
|---|---|---|---|---|
| Treatmenta | ||||
| Mitotane | 10 μM | 30 μM | 10 μM | 30 μM |
| 0 | 86.9 | 0 | 15.4 | |
| Mitotaneb | 48.1 | |||
| + Mitotane (10 μM) | + Mitotane (30 μM) | |||
|---|---|---|---|---|
| Everolimus (10 μM) | 29.7 | 49.3 | 0 | 32.1 |
| Sunitinib (5 μM) | 58.2 | 76.2 | 20.3 | 23.6 |
| Zol Acid (10 μM) | 19.5 | 30.1 | 0 | 0 |
| Imatinib (10 μM) | 27.2 | 50.3 | 0 | 18.1 |
| Nilotinib (10 μM) | 62.8 | 70.2 | 39.6 | 56.0 |
| Nilotinibb (10 μM) | 67.2 | 62.5 | 62.0 | 60.0 |
ACC adrenocortical carcinoma
aFor 72 h
bACC-T36
