Table 1.

Meta-regression of Study Factors Predictive for Death, Neurosurgery, and Clinical Deterioration

Factor	Outcome	Unit increase affect odds uni-variable model	Unit increase affect odds multi-variable model
Mean age study population	Death	1.05 (95% CI: 1.0003–1.12), p = 0.049	1.06 (95% CI: 1.0002–1.12), p = 0.049
Mean GCS study population	Death	0.12 (95% CI: 0.02–0.86), p = 0.04	0.09 (95% CI: 0.01–0.59), p = 0.02
Lower-risk study population vs. ICU population	Death	0.27 (95% CI: 0.08–0.94), p = 0.04
Unselected study population vs. ICU population	Death	0.81 (95% CI: 0.22–1.97), p = 0.63
Percentage population anti-coagulated	Death	1.05 (95% CI: 0.95–1.17), p = 0.32
Mean age study population	Neurosurgery	1.01 (95% CI: 1.02–1.11), p = 0.01	1.09 (95% CI: 1.02–1.16), p = 0.02
Mean GCS study population	Neurosurgery	0.71 (95% CI: 0.01–0.56), p = 0.01	0.12 (95% CI: 0.02–0.91), p = 0.04
Lower-risk study population vs. ICU population	Neurosurgery	0.13 (95% CI: 0.04–0.41), p < 0.01	0.67 (95% CI: 0.10–4.37), p = 0.66
Unselected study population vs. ICU population	Neurosurgery	0.95 (95% CI: 0.43–2.12), p = 0.90	1.34 (95% CI: 0.45–4.02), p = 0.58
Percentage population anti-coagulated	Neurosurgery	1.1 (95% CI: 1.01–1.19), p = 0.04
Exclusion of anti-coagulated patients in study selection	Neurosurgery	0.63 (95% CI: 0.27–1.43), p = 0.26	1.33 (95% CI: 0.51–3.49), p = 0.54
Mean age study population	Clinical deterioration	1.01 (95% CI: 0.95–1.09), p = 0.64	1.02 (95% CI: 0.93–1.12), p = 0.59
Mean GCS study population	Clinical deterioration	0.36 (95% CI: 0.04–3.20), p = 0.33	0.26 (95% CI: 0.02–3.76), p = 0.29

CI, confidence interval; ICU, intensive care unit; GCS, Glasgow Coma Scale.