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. 2018 Feb 15;14(2):e1007225. doi: 10.1371/journal.pgen.1007225

Fig 3. Depletion of Pds5 causes extension of cohesin and accessory factor binding domains surrounding replication origins.

Fig 3

(A) Genome browser view of the kayak origin region, showing ChIP-seq for Wapl, Rad21, SA, and Nipped-B in control cells and cells depleted for Pds5 (iPds5). Shaded areas show regions with increased binding of cohesin, Wapl and Nipped-B in Pds5-depleted cells. (B) The left panel shows the Rad21 meta-origin analysis in mock control cells (Rad21, blue) and cells depleted for Pds5 (Rad21 iPds5, red). The right panel shows the–log10 p values for differences in Rad21 enrichment in each bin used for the meta-origin analysis. P values were calculated using the Wilcoxon signed rank test.