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. 2018 Mar 1;18:239. doi: 10.1186/s12885-018-4131-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Tumor histology of patient P3. At initial diagnosis, H&E stain (a, 200X) reveals a high-grade glioma with pleomorphic tumor cells (arrows), increased mitotic figures (arrowheads), and areas of necrosis (stars). Histiocytes are minimal in number as stained by KP-1 (b, 200X). MIB-1 shows a high proliferative rate index (c, 200X). At 8.5 months after the initiation of ipilimumab, a new biopsy of the tumor still shows on H&E (d, 200X) a high-grade glial neoplasm with increased cellularity and mitotic figures. Reactive changes are present and abundant histiocytes are identified with KP-1 stain (e, 200X). MIB-1 demonstrates a high proliferative rate index, up to 40% in some areas. Scale bar for all panels measures 150 μm