Table 2.
Baseline Skeletal and Anthropometric Measures (Unadjusted) Split Based on Treatment Assignment (Mean ± Standard Deviation)
| Placebo, n = 24 | Ca+VitD, n = 23 | p | |
|---|---|---|---|
| Dual-energy X-ray absorptiometry-based measures | |||
| TBLH BMC | 1259 ± 648 | 1035 ± 483 | >0.20 |
| TBLH BMC Z-score | 0.12 ± 0.68 | 0.10 ± 0.79 | >0.80 |
| FMI Z-score | 0.28 ± 0.77 | 0.79 ± 0.64 | <0.04 |
| Lean mass index Z-score | −0.79 ± 0.88 | −0.53 ± 0.79 | >0.30 |
| Visceral fat mass, g | 219 ± 103 | 242 ± 93 | >0.20 |
| pQCT-based measures | |||
| Trabecular bone mineral density, mg/cm3 | 197.2 ± 43.9 | 192.9 ± 31.1 | >0.90 |
| Strength index, mg2/mm4 | 25.3 ± 15.9 | 19.8 ± 8.1 | >0.50 |
| Cortical bone mineral density, mg/cm3 | 1063.2 ± 30.6 | 1059.6 ± 34.8 | >0.90 |
| Cortical thickness, mm | 2.3 ± 0.5 | 2.2 ± 0.3 | >0.90 |
| Periosteal circumference, mm | 32.4 ± 5.4 | 30.1 ± 4.3 | >0.20 |
| Endosteal circumference, mm | 17.7 ± 3.6 | 16.0 ± 3.4 | >0.10 |
| Polar section modulus, mm3 | 156.2 ± 76.6 | 123.8 ± 53.6 | >0.20 |
At the 4% radius site, 21 placebo and 22 Ca+VitD participants had useable pQCT data, while at the 20% radius site, 20 and 18 participants, respectively, had useable data. Age-sex-height-race-specific Z-scores for TBLH BMC were generated following the bone mineral density in childhood study. Significant results (p < 0.05) are bolded.
BMC, bone mineral content; BMI, body mass index; Ca+VitD, calcium and vitamin D3; FMI, fat mass index; pQCT, peripheral quantitative computed tomography; TBLH, total body less head.