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. 2016 Dec 10;4(4):35. doi: 10.3390/jdb4040035

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Hedgehog (Hh) signaling spans nervous system development. Hh interacts with different receptors, co-receptors and interacting proteins to recruit canonical, glioma-associated oncogene (Gli)-dependent or non-canonical signaling pathways regulating the cellular events that encompass neural development and function. Boc: brother of cell adhesion molecule-related/down-regulated by oncogenes (Cdon); Boi: brother of interference hedgehog (Ihog); Gas1: growth-arrest specific gene-1; Ptch: Patched; Smo: Smoothened.