Table 2.
The mean values of first tacrolimus blood trough level after kidney transplantation (left column) and the proportion of patients with first tacrolimus blood trough level exceeding 15 ng/ml (right column), presented in subgroups of patients with or without the presence of potential risk factor.
| Tc first level [ng/ml] | Tc > 15 ng/ml n [%] |
|
|---|---|---|
| Gender | ||
| Men (n = 323) | 15.3 (14.5–16.1)∗∗ | n = 136 (42.1) ∗ |
| Women (n = 165) | 13.4 (12.5–14.4) | n = 53 (32.1) |
|
| ||
| Nutritional status | ||
| Underweight (n = 23) | 12.2 (9.5–14.8) | n = 6 (26.1) |
| Normal weight (n = 247) | 12.6 (11.8–13.4) | n = 66 (26.7) |
| Overweight (n = 182) | 16.9 (15.9–18.0)∧∧∧ | n = 95 (52.2) ∧∧∧ |
| Obesity (n = 36) | 18.7 (16.1–21.2)∧∧∧ | n = 22 (61.1) ∧∧∧ |
|
| ||
| Diabetes mellitus | ||
| Yes (n = 44) | 17.1 (14.8–19.4)∗ | n = 25 (56.8) ∗ |
| No (n = 444) | 14.4 (13.7–15.1) | n = 164 (36.9) |
|
| ||
| Anti-HCV positive | ||
| Yes (n = 35) | 17.0 (14.3–19.6) ∗ | n = 19 (54.3) ∗ |
| No (n = 453) | 14.6 (14.0–15.3) | n = 170 (37.5) |
|
| ||
| HBs positive | ||
| Yes (n = 16) | 15.7 (11.5–20.0) | n = 8 (50) |
| No (n = 462) | 14.8 (14.1–15.4) | n = 173 (37.4) |
|
| ||
| ALT > 40 IU/L | ||
| Yes (n = 51) | 14.6 (12.6–16.5) | n = 19 (37.3) |
| No (n = 421) | 14.7 (14.1–15.4) | n = 165 (39.4) |
|
| ||
| AST > 40 IU/L | ||
| Yes (n = 18) | 17.5 (13.3–21.7) | n = 9 (50.0) |
| No (n = 434) | 14.6 (13.9–15.2) | n = 168 (38.9) |
|
| ||
| AST/ALT > 1 | ||
| Yes (n = 162) | 15.1 (14.0–16.2) | n = 68 (42.0) |
| No (n = 286) | 14.4 (13.6–15.3) | n = 108 (37.8) |
|
| ||
| Anemia | ||
| Severe (n = 77) | 12.6 (11.1–14.2)### | n = 21 (27.3) ### |
| Mild (n = 219) | 13.2 (12.4–14.1)### | n = 65 (29.7) ### |
| No (n = 192) | 17.1 (16.0–18.2) | n = 103 (53.6) |
|
| ||
| Transplant No | ||
| First (n = 421) | 14.7 (14.1–15.4) | n = 164 (39.0) |
| Next (n = 67) | 14.5 (12.7–16.3) | n = 25 (37.3) |
|
| ||
| Early graft function | ||
| IGF (n = 121) | 14.1 (12.8–15.4) | n = 41 (33.9) |
| SGF (n = 228) | 15.0 (14.0–16.0) | n = 89 (39.0) |
| DGF (n = 137) | 15.1 (13.8–16.3) | n = 59 (42.1) |
|
| ||
| H2-blocker | ||
| Yes (n = 152) | 13.5 (12.4–14.5)∗ | n = 48 (31.6) ∗ |
| No (n = 336) | 15.2 (14.4–16.0) | n = 141 (42.0) |
|
| ||
| PPI | ||
| Yes (n = 354) | 14.9 (14.2–15.6) | n = 140 (39.5) |
| No (n = 134) | 14.0 (12.8–15.3) | n = 49 (36.6) |
Data shown as means ± 95% CI or frequencies. BMI: body mass index, HCV: hepatitis C virus, HBs: hepatitis B surface antigen, IGF: immediate graft function, SGF: slow graft function, DGF: delayed graft function. Statistical significance: ∧∧∧p < 0.001 versus normal weight; ###p < 0.001 versus no anemia, ∗p < 0.05 or ∗∗p <0.01 versus the second value without the presence of risk factor.