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. 2018 Feb 28;16:47. doi: 10.1186/s12967-018-1421-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Apatinib induces apoptosis of both B and T lineage ALL cells in a dose and time-dependent manner. B-lineage (a, b) and T-lineage ALL cells (c, d) were treated with indicated doses of Apatinib for 48 or 72 h, and the percentage of apoptotic cells was examined by Annexin V/PI double staining. *P < 0.05; **P < 0.01; ***P < 0.001