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. 2018 Feb 28;16:47. doi: 10.1186/s12967-018-1421-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Apatinib shows preferential cytotoxic activity against primary adult ALL cells while sparing normal PBMCs. The percentage of apoptotic cells (Annexin V+) of primary ALL patients (a) and peripheral blood or bone marrow of healthy donors (b) after exposure to indicated doses of Apatinib for 48 h. *P < 0.05; **P < 0.01