Fig. 6.

Apatinib suppresses leukemia cell growth and leukemia progression in a xenograft model. Nalm6 cells were intravenously injected into NSI mice. 7 days later, mice were randomized (n = 6 per group) and treated with vehicle (control group) or Apatinib (administered by oral gavage at the dose of 100 mg/kg for 2 consecutive weeks). Percentage of human CD45+ (hCD45) cells in peripheral blood (a), bone marrow (b) and spleen (c) were determined by flow cytometry. d Spleens of mice were weighted at the end of the experiment. e Spleen and bone marrow of mice were embedded with paraffin and stained with H&E. Scale bar, 25 μm.*P < 0.05; **P < 0.01