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. 2018 Mar 1;6:19. doi: 10.1186/s40478-018-0524-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Inter-modular relationships and module expression profiles of AD-related modules. a Module eigenprotein meta-network showing the inter-modular relationships of the identified 24 protein co-expression modules. b Box plots showing module eigenprotein (ME) values in AD and control (CT) cases for modules that are positively correlated with AD phenotypes. c Box plots showing ME values in AD and CT cases for modules that are negatively correlated with AD phenotypes. Box plots depict the mean (horizontal bars) and variance (25th to 75th percentiles), and significance (P-value) of differential ME expression in AD versus control was determined using unpaired two-tailed Student’s t test