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. 2018 Mar 1;6:19. doi: 10.1186/s40478-018-0524-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Hub proteins of AD-related modules provide a molecular signature for differentiating AD and control cases. a Venn diagram showing the overlap between the identified up-regulated proteins in AD and top intramodular hub proteins of co-expression modules with positive correlation to AD phenotypes. b Venn diagram showing the overlap between the identified down-regulated proteins in AD and top intramodular hub proteins of co-expression modules with negative correlation to AD phenotypes. c Heat map representing the expression profiles of 110 highly connected intramodular hub proteins after unsupervised hierarchical clustering, showing clear separation of AD from control (CT) cases and positively correlated module hub proteins from negatively correlated module hub proteins