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. 2018 Mar 1;20:39. doi: 10.1186/s13075-018-1537-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Pharmacokinetics of CR6086 in rats. a Unbound concentrations of CR6086 administered orally in the dose range of 1–30 mg/kg. The dashed line represents the inhibition constant (36.2 ng/ml) value for the rat prostaglandin E₂ receptor 4. b Pharmacokinetic parameters