Table 1.

Mechanical hyperalgesia: effect of repeated administration of CR6086 and rofecoxib in arthritic rats (collagen-induced arthritis model)

	Day 0 (gram-force)	Day 7 (gram-force)	Day 14 (gram-force)
Sham	1174.59 ± 48.41	1040.32 ± 53.38	1074.66 ± 45.60
Vehicle	894.81 ± 69.51a	666.79 ± 49.15b	600.42 ± 50.23b
15 mg/kg CR6086	850.45 ± 59.57a	846.33 ± 43.60b,c	1023.09 ± 53.97d
15 mg/kg rofecoxib	943.70 ± 73.42a	673.18 ± 53.76b	799.68 ± 61.15b,c

Results are reported as mean ± SEM for each group

^aP < 0.05 vs sham rats

^bP < 0.001 vs sham rats

^cP < 0.05 vs vehicle-treated arthritic rats (one-way analysis of variance [ANOVA] followed by multiple comparisons test)

^dP < 0.001 vs vehicle-treated arthritic rats (one-way ANOVA followed by multiple comparisons test)