Table 2.

Fluorescence-activated cell sorting analysis of cell populations in the joint

Cell population	Percentage of total cells
	Vehicle	Etanercept	CR6086	Naproxen
Th1	0.32 ± 0.03	0.20 ± 0.05a	0.14 ± 0.03b	0.35 ± 0.07
Th17	0.20 ± 0.03	0.16 ± 0.08	0.06 ± 0.01b	0.21 ± 0.08
Treg	0.54 ± 0.12	0.39 ± 0.10	0.38 ± 0.12	0.63 ± 0.22
B cells	5.00 ± 0.53	5.74 ± 0.68	6.65 ± 0.72	5.77 ± 1.16
Neutrophils	19.04 ± 4.23	10.53 ± 2.81	9.98 ± 2.89a	16.47 ± 4.48
Macrophages	20.81 ± 4.44	12.31 ± 5.19	11.14 ± 2.93a	16.31 ± 4.44
Dendritic cells	2.31 ± 0.62	1.51 ± 0.18	1.72 ± 0.44	1.96 ± 0.48

Th T-helper cell, Treg Regulatory T cell

Results are reported as mean percentage ± SEM in each group

^aP < 0.05 vs collagen-induced arthritis (CIA) mice treated with vehicle by paired two-tailed t test

^bP < 0.01 vs CIA mice treated with vehicle by paired two-tailed t test