Table 1.
Characteristics of study subjects
| Characteristics | Control (n = 14) | AD for TDP and FDG-PET (n = 14) | AD for TDP and PiB-PET (n = 35) | AD for FDG and PiB-PET (n = 23) |
|---|---|---|---|---|
| Male sex, n (%) | 6 (42.9) | 6 (42.9) | 20 (47.1%) | 14 (60.9%) |
| Age, years | 68.1 ± 2.9 | 69.3 ± 2.7 | 69.4 ± 10.9 | 68.6 ± 7.83 |
| Education level, years | 13.4 ± 0.6 | 7.5 ± 1.2a | 9.9 ± 1.46 | 8.3 ± 0.75 |
| MMSE score | 29.1 ± 0.2 (26-30) | 16.6 ± 1.4 (6-24)a | 17.6 ± 7.0 a | 15.3 ± 8.14a |
| APOE ε4, n (%) | 3 (23.1%)b | 10 (71.4%)a | 19 (54.3%)a | 10 (43.5%)a |
| Folate, ng/ml | – | 8.8 ± 0.7 | 9.72 ± 0.90 | 22.9 ± 3.12 |
| Vitamin B12, pg/ml | – | 499.6 ± 59.1 | 489.2 ± 47.2 | 329.4 ± 77.5 |
| TDP, nmol/L | 117.1 ± 4.7 | 84.9 ± 7.1a | 101.3 ± 30.3a | – |
| SUVR of FDG or PiB in frontal cortex | 1.25 ± 0.030 | 1.10 ± 0.055a | 1.9 ± 0.5 | 1.04 ± 0.02a1.9 ± 0.5 |
| SUVR of FDG or PiB in temporal cortex | 1.17 ± 0.028 | 0.95 ± 0.051a | 1.7 ± 0.5 | 1.05 ± 0.02a2.00 ± 0.08 |
| SUVR of FDG or PiB in parietal cortex | 1.16 ± 0.031 | 0.97 ± 0.044a | 1.7 ± 0.4 | 0.92 ± 0.02a1.96 ± 0.07 |
Abbreviations: AD Alzheimer’s disease, APOE Apolipoprotein E, FDG 2-[18F]fluoro-2-deoxy-d-glucose, MMSE Mini Mental State Examination, PET Positron emission tomography, PiB 11C-Pittsburgh compound B, SUVR 2-[18F]fluoro-2-deoxy-d-glucose standardized uptake value ratio, TDP Thiamine diphosphate
Data are presented as mean ± SEM or count (percent)
aP < 0.001 vs. control
bUnable to determine for one subject