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Schematic representation of feedback loops regulating the calcineurin/NFAT signaling pathway. In a negative feedback loop (type 1), miRNAs transcribed by NFAT inhibit NFAT activation, whereas in a positive feedback loop (type 2), miRNAs transcribed by NFAT repress the expression of the NFAT inhibitor which results in the activation of NFAT.
