Table 3.
Selected lncRNAs among the most differentially connected (top 20%) DEGs between co-expression networks from elderly and adults that show an average local similarity greater than the median similarity of enriched pathways related to cellular respiration in at least one network, and show an inverted expression pattern between networks. The average fold-changes (FCs) between sepsis and control subjects for each age group are shown. Significant p values are in bold.
| Sepsis vs. Control | |||||||
|---|---|---|---|---|---|---|---|
| Gene | Connectivity | Type | Elderly | Adults | |||
| Elderly | Adults | FC | p Value | FC | p Value | ||
| RP11-383M4.6 | 15.0 | 450 | lincRNA | 0.97 | 7.4 × 10−1 | 1.86 | 3.2 × 10−3 |
| CTC-293G12.1 | 10.8 | 414 | lincRNA | 0.94 | 5.2 × 10−1 | 1.95 | 5.2 × 10−3 |
| lnc-THUMPD3-1 | 3.7 | 397 | ncRNA | 0.94 | 7.2 × 10−1 | 2.25 | 9.7 × 10−4 |
| RP11-121L11.3 | 16.9 | 372 | lincRNA | 0.98 | 7.8 × 10−1 | 1.86 | 4.0 × 10−3 |
| MYCNOS | 4.0 | 298 | antisense | 0.95 | 6.7 × 10−1 | 1.76 | 9.6 × 10−3 |
| MALAT1 | 6.6 | 281 | lincRNA | 1.21 | 5.0 × 10−1 | 0.37 | 2.0 × 10−4 |
| AC010970.2 | 7.3 | 280 | pseudogene | 0.92 | 5.8 × 10−1 | 1.86 | 4.1 × 10−3 |
| RPL10P3 | 14.9 | 274 | pseudogene | 1.11 | 8.4 × 10−1 | 0.41 | 8.0 × 10−4 |
| SNORD11 | 5.6 | 237 | snoRNA | 1.25 | 4.0 × 10−1 | 0.38 | 3.5 × 10−4 |
| RPL13P5 | 1.7 | 235 | pseudogene | 0.91 | 8.6 × 10−1 | 2.37 | 6.0 × 10−4 |
| LINC00355 | 291 | 11.0 | lincRNA | 1.79 | 5.3 × 10−3 | 0.96 | 7.3 × 10−1 |