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Biogenesis of tRNA-derived small RNAs (tDRs). In eukaryotic cells, precursor tRNAs undergo processing and become mature tRNAs. The cleavage of precursor tRNAs generates tRNA-derived small RNA fragments (tRF-1s) and 5’ leader-exon tRFs. tRF-5s, tRF-3s, i-tRFs, 5’ halves and 3’ halves are generated by the cleavage of mature tRNAs.
