Table 2.
Serum biochemical values in rats orally treated with Wei Bi Mei at withdrawal at 0, 4, 8, and 12 weeks after bismuth exposure.
| Parameter | Time | |||||||
|---|---|---|---|---|---|---|---|---|
| 0 | 4 w | 8 w | 12 w | |||||
| Wei Bi Mei | Water | Wei Bi Mei | Water | Wei Bi Mei | Water | Wei Bi Mei | Water | |
| ALT (U/L) | 40 (6) | 38 (3) | 42 (4) | 47 (6) | 43 (5) | 41 (6) | 41 (3) | 42 (3) |
| AST (U/L) | 100 (27) | 134 (23) | 110 (39)∗ | 116 (29) | 97 (31) | 82 (10) | 112 (25) | 109 (21) |
| ALP (U/L) | 163 (24) | 183 (67) | 206 (57) | 207 (50) | 150 (29) | 153 (31) | 155 (30) | 172 (77) |
| GLU (mmol/L) | 5.8 (0.9) | 5.2 (0.4) | 5.45 (0.8) | 5.6 (0.5) | 5.85 (0.8) | 5.2 (0.3) | 5.2 (0.4) | 5.4 (0.4) |
| TP (g/L) | 56 (6) | 56 (3) | 55 (4) | 55 (3) | 53 (3) | 57 (4) | 54 (5) | 54 (3) |
| ALB (g/L) | 28 (2) | 29 (20) | 29 (2) | 28 (3) | 28 (1) | 27 (2) | 28 (1) | 30 (2) |
| T-BIL (µmol/L) | 7.35 (1.89) | 7.26 (1.96) | 7.48 (1.44) | 6.68 (1.25) | 6.58 (1.78) | 7.95 (1.01) | 7.21 (1.13) | 7.47 (1.38) |
| D-BIL (µmol/L) | 4.01 (0.94) | 4.6 (1.32) | 3.98 (1.37) | 4.06 (0.72) | 3.75 (1.16) | 5.28 (0.49) | 3.93 (0.91) | 4.08 (0.96) |
| Cre (µmol/L) | 38 (5) | 40 (3) | 36 (5) | 33 (8) | 30 (6) | 33 (6) | 36 (5) | 37 (4) |
| Bun (mmol/L) | 5.70 (1.25) | 6.00 (1.26) | 6.03 (0.83) | 6.57 (0.98) | 6.21 (1.65) | 7.28 (2.47) | 5.91 (0.667) | 6.38 (1.16) |
| Na+ (mmol/L) | 141.2 (4.7) | 144.3 (2.0) | 143.4 (4.1) | 143.9 (1.73) | 141.4 (2.9) | 141.7 (2.5) | 140 (4.0) | 139 (1.4) |
| K+ (mmol/L) | 4.23 (0.39) | 4.31 (0.43) | 4.62 (0.49) | 4.59 (0.47) | 4.58 (0.48) | 4.30 (0.34) | 4.11 (0.31) | 4.56 (0.33) |
| Cl− (mmol/L) | 100.2 (4.2) | 97.7 (2.1) | 103.5 (5.2)∗∗ | 96.5 (1.9) | 100.7 (4.7) | 96.8 (1.5) | 99.6 (4.7) | 100.4 (1.7) |
Alanine aminotransferase activity (ALT), aspartate aminotransferase activity (AST), alkaline phosphatase activity (ALP), glucose (GLU), total protein (TP), albumin (ALB), total bilirubin (T-BIL), direct bilirubin (D-BIL), creatinine (CRE), blood urea nitrogen (BUN), potassium ions (K+), sodium ions (Na+), and chloride ions (Cl−). Colloidal bismuth subcitrate (CBS); values are mean (SD); ∗P < 0.05 and ∗∗P < 0.01 when compared to the controls using the independent t-test.