Table 3.
Serum biochemical values in rats orally treated with bismuth aluminate at withdrawal at 0, 4, 8, and 12 weeks after bismuth exposure.
| Parameter | Time | |||||||
|---|---|---|---|---|---|---|---|---|
| 0 | 4 w | 8 w | 12 w | |||||
| Bismuth aluminate | Water | Bismuth aluminate | Water | Bismuth aluminate | Water | Bismuth aluminate | Water | |
| ALT (U/L) | 40 (3) | 38 (3) | 45 (3) | 47 (6) | 38 (5) | 41 (6) | 39 (3) | 42 (3) |
| AST (U/L) | 128 (24) | 134 (23) | 94 (35) | 116 (29) | 95 (14) | 82 (10) | 97 (23) | 109 (21) |
| ALP (U/L) | 139 (51) | 183 (67) | 174 (79) | 207 (50) | 169 (59) | 153 (31) | 172 (77) | 172 (77) |
| GLU(mmol/L) | 5.31 (0.9) | 5.2 (0.4) | 5.76 (5.55) | 5.6 (0.5) | 5.55 (0.81) | 5.2 (0.3) | 5.4 (0.5) | 5.4 (0.4) |
| TP (g/L) | 53 (3) | 56 (3) | 55 (4) | 55 (3) | 56 (3) | 57 (4) | 54 (3) | 54 (3) |
| ALB (g/L) | 27 (2) | 29 (2) | 29 (2) | 28 (3) | 28 (2) | 27 (2) | 30 (1) | 30 (2) |
| T-BIL(µmol/L) | 7.03 (2.01) | 7.26 (1.96) | 7.2 (1.59) | 6.68 (1.25) | 7.08 (1.47) | 7.95 (1.01) | 7.30 (1.21) | 7.47 (1.38) |
| D-BIL(µmol/L) | 4.20 (1.09) | 4.60 (1.32) | 4.70 (1.27) | 4.06 (0.72) | 4.08 (1.05) | 5.28 (0.49) | 4.02 (0.73) | 4.08 (0.96) |
| Cre (µmol/L) | 41 (4) | 40 (3) | 31 (5) | 33 (8) | 32 (10) | 33 (6) | 36 (4) | 37 (4) |
| Bun (mmol/L) | 5.63 (0.70) | 6.00 (1.26) | 7.51 (0.71) | 6.57 (0.98) | 6.09 (1.03) | 7.28 (2.47) | 5.85 (0.99) | 6.38 (1.16) |
| Na+ (mmol/L) | 143 (1.8) | 144 (2.0) | 140 (1.2)∗∗ | 143.9 (1.73) | 142.7 (2.9) | 142 (2.5) | 143 (2.4) | 139 (1.4) |
| K+ (mmol/L) | 5.00 (0.25)∗∗ | 4.31 (0.43) | 4.67 (0.35) | 4.59 (0.47) | 4.02 (0.33) | 4.30 (0.34) | 4.47 (0.35) | 4.56 (0.33) |
| Cl− (mmol/L) | 102 (5.1) | 97.7 (2.1) | 101 (4.6)∗ | 96.5 (1.9) | 96.9 (3.4) | 96.8 (1.5) | 98.3 (3.2) | 100 (1.7) |
Alanine aminotransferase activity (ALT), aspartate aminotransferase activity (AST), alkaline phosphatase activity (ALP), glucose (GLU), total protein (TP), albumin (ALB), total bilirubin (T-BIL), direct bilirubin (D-BIL), creatinine (CRE), blood urea nitrogen (BUN), potassium ions (K+), sodium ions (Na+), and chloride ions (Cl−). Colloidal bismuth subcitrate (CBS); values are mean (SD); ∗P < 0.05 and ∗∗P < 0.01 when compared to the controls using the independent t-test.