Table 4.
Serum biochemical values in rats orally treated with CBS at withdrawal at 0, 4, 8, and 12 weeks after bismuth exposure.
| Parameter | Time | |||||||
|---|---|---|---|---|---|---|---|---|
| 0 | 4 w | 8 w | 12 w | |||||
| CBS | Water | CBS | Water | CBS | Water | CBS | Water | |
| ALT (U/L) | 40 (8) | 38 (3) | 46 (6) | 47 (6) | 39 (4) | 41 (6) | 42 (6) | 42 (3) |
| AST (U/L) | 84 (13)∗∗ | 134 (23) | 131 (40) | 116 (29) | 98 (25) | 82 (10) | 123 (22) | 109 (21) |
| ALP (U/L) | 187 (54) | 183 (67) | 202 (31) | 207 (50) | 209 (47) | 153 (31) | 151 (29) | 172 (77) |
| GLU (mmol/L) | 5.4 (0.4) | 5.2 (0.4) | 5.90 (0.8) | 5.6 (0.5) | 5.5 (0.6) | 5.2 (0.3) | 5.1 (0.4) | 5.4 (0.4) |
| TP (g/L) | 53 (3) | 56 (3) | 54 (2) | 55 (3) | 53 (3) | 57 (4) | 54 (2) | 54 (3) |
| ALB (g/L) | 30 (1) | 29 (2) | 27 (2) | 28 (3) | 28 (3) | 27 (2) | 27 (2) | 30 (2) |
| T-BIL (µmol/L) | 8.36 (0.93) | 7.26 (1.96) | 8.13 (1.06) | 6.68 (1.25) | 7.58 (1.60) | 7.95 (1.01) | 7.4 (1.29) | 7.47 (1.38) |
| D-BIL (µmol/L) | 5.36 (0.93) | 4.6 (1.32) | 4.96 (1.07) | 4.06 (0.72) | 4.05 (1.06) | 5.28 (0.49) | 4.02 (0.64) | 4.08 (0.96) |
| Cre (µmol/L) | 38 (7) | 40 (3) | 34 (4) | 33 (8) | 30 (5) | 33 (6) | 36 (4) | 37 (4) |
| Bun (mmol/L) | 5.56 (1.01) | 6.00 (1.26) | 6.96 (1.42) | 6.57 (0.98) | 6.43 (0.97) | 7.28 (2.47) | 5.80 (0.51) | 6.38 (1.16) |
| Na+ (mmol/L) | 143 (2.3) | 144 (2.0) | 140 (1.50)∗∗ | 144 (1.73) | 142 (2.3) | 142 (2.5) | 142 (2.3) | 139 (1.4) |
| K+ (mmol/L) | 4.43 (0.56) | 4.31 (0.43) | 4.37 (0.70) | 4.59 (0.47) | 4.75 (0.33) | 4.30 (0.34) | 4.21 (0.45) | 4.56 (0.33) |
| Cl− (mmol/L) | 98.4 (0.8) | 97.7 (2.1) | 98.1 (2.70) | 96.5 (1.9) | 99.2 (1.9) | 96.8 (1.5) | 101 (2.0) | 100 (1.7) |
Alanine aminotransferase activity (ALT), aspartate aminotransferase activity (AST), alkaline phosphatase activity (ALP), glucose (GLU), total protein (TP), albumin (ALB), total bilirubin (T-BIL), direct bilirubin (D-BIL), creatinine (CRE), blood urea nitrogen (BUN), potassium ions (K+), sodium ions (Na+), chloride ions (Cl−). Colloidal bismuth subcitrate (CBS); values are mean (SD); ∗P < 0.05 and ∗∗P < 0.01 when compared to the controls using the independent t-test.