Table 4.
Cox proportional hazard regression analysis of patients' progression-free survival.
| Variables | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (≤54/>54) | 1.244 (0.709–2.184) | 0.446 | ||
| Gender (F/M) | 0.854 (0.486–1.502) | 0.585 | ||
| Tumor location (pyloric/nonpyloric antrum) | 1.17 (0.667–2.053) | 0.584 | ||
| HER-2 (positive/negative) | 1.315 (0.614–2.816) | 0.481 | ||
| RDW (≤13.4%/>13.4%) | 1.672 (0.943–2.964) | 0.078 | ||
| WBC (≤5.69/>5.69 g/L) | 2.175 (1.227–3.856) | 0.008 | 1.600 (0.781–3.277) | 0.199 |
| MO (≤0.42/>0.42 g/L) | 1.870 (1.059–3.302) | 0.031 | 0.987 (0.475–2.048) | 0.971 |
| NLR (≤2.755/>2.755) | 4.187 (2.328–7.529) | <0.001 | ||
| CA125 (≤26.6/>26.6 U/mL) | 1.897 (1.077–3.343) | 0.027 | 1.645 (0.918–2.945) | 0.094 |
| CA199 (≤11.9/>11.9 U/mL) | 1.288 (0.733–2.264) | 0.379 | ||
| CEA (≤2.4/>2.4 μg/L) | 1.609 (0.916–2.827) | 0.098 | ||
| RDW + NLR | 1.923 (0.941–3.927) | <0.001 | 2.016 (0.982–4.136) | <0.001 |
HR: hazard ratio; CI: confidence interval; RDW: red cell distribution width; MO: monocyte; NLR: neutrophil-to-lymphocyte ratio; RDW + NLR: combination of red blood cell distribution width and neutrophil-to-lymphocyte ratio. P less than 0.05 is statistically significant. Univariate and multivariate analysis performed using Cox proportional hazards models. Multivariate analyses using the 4 significant variables (WBC, MO, CA125, and RDW + NLR, except NLR) above were performed. Significant factors in univariate and multivariate analysis are indicated in bold.