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. 2018 Mar 1;13(3):e0193684. doi: 10.1371/journal.pone.0193684

Table 1. HLA class II pocket epitopes associated with type 1 diabetes.

Location EPITOPE PATIENT (N = 170) CONTROL (N = 192) Pcorr. Value OR Associated alleles
DRB1 13 H 110 37 8.8x10-17 7.57 04:05, 04:02, 04:01, 04:04, 04:08, 04:07, 04:03
70 Q 158 97 3.6x10-18 12.42 03:01, 04:05, 04:01, 04:04, 04:08, 01:02, 04:07, 15:06, 01:01, 15:02, 04:03, 15:01
70 D 84 157 7.4x10-9 0.22 04:02, 08:04, 13:05, 16:05, 13:02, 16:01, 11:02, 11:03, 12:01, 13:03, 13:01, 07:01, 11:01, 16:02, 11:04
70 R 2 52 8.2x10-12 0.04 10:01, 14:01
71 K 91 33 3.0x10-11 5.48 03:01, 04:01, 13:03
71 R 132 185 5.12x10-6 0.14 04:05, 04:04, 08:04, 04:08, 13:05, 16:05, 01:02, 16:01, 04:07, 01:01, 12:01, 04:03, 07:01, 11:01, 16:02, 10:01, 11:04, 14:01
74 R 106 24 4.2x10-12 6.6 03:01
74 E 8 46 1.4x10-5 0.17 04:07, 04:03, 14:01
DQA1 11 Y 165 141 4.2x10-9 11 03:01, 05:01, 04:01, 02:01
11 C 82 153 3.0x10-8 0.21 01:03, 01:02, 01:01
55 R 165 141 4.2x10-9 11 03:01, 05:01, 04:01, 02:01
55 G 82 153 3.0x10-8 0.24 01:03, 01:02, 01:01
66 I 165 141 4.2x10-9 11 03:01, 05:01, 04:01, 02:01
66 M 82 153 3.0x10-8 0.24 01:03, 01:02, 01:01
69 L 165 141 4.2x10-9 11 03:01, 05:01, 02:01
69 A 82 153 3.0x10-8 0.24 01:03, 01:02, 01:01
DQB1 26 L 161 92 1.4x10-22 18.47 02:01, 03:02, 03:03, 06:04, 02:03, 06:02, 06:03
26 Y 17 88 1.1x10-12 0.14 03:04, 06:01, 03:01
26 G 78 140 1.9x10-5 0.32 04:02, 03:05, 05:02, 05:01, 05:03
47 F 121 54 1.6x10-14 6.2 02:01, 02:03
47 Y 140 189 4.0x10-6 0.09 03:02, 03:03, 03:04, 04:02, 06:04, 06:01, 03:05, 06:02, 06:03, 05:02, 05:01, 05:03, 03:01
57 A 160 78 1.3x10-27 22.3 02:01, 03:02, 03:04, 03:05
57 D 17 121 4.5x10-25 0.07 03:03, 04:02, 02:03, 06:01, 06:02, 06:03, 05:03, 03:01
70 R 166 145 1.6x10-8 12.1 02:01, 03:02, 03;03, 03:04, 06:04, 02:03, 06:01, 03:05, 03:01
70 G 77 146 1.8x10-7 0.26 06:02, 06:03, 05:02, 05:01, 05:03