Table 4. HLA class II genotypes of type 1 diabetes patients and control subjects.
| HLA class II Genotype | Patients (%) (N = 170) | Control subjects (%) (N = 192) | P value | OR |
|---|---|---|---|---|
| DR3—DQ2.5 / DRX | 30 (17.65) | 22 (11.46) | 0.1 | 1.66 |
| DR3—DQ2.5 / DR3—DQ2.5 | 18 (10.59) | 0 | <0.0001 | 46.7 |
| DR3—DQ2.5 / DR4—DQ2.3 | 5 (2.94) | 1 (0.52) | 0.1 | 5.79 |
| DR4—DQ8 / DRX | 43 (25.29) | 18 (9.38) | <0.0001 | 3.27 |
| DR4—DQ8 / DR4—DQ8 | 5 (2.94) | 1 (0.52) | 0.1 | 5.79 |
| DR4—DQ8 / DR4—DQ2.3 | 4 (2.35) | 0 | 0.047 | 10.41 |
| DR3—DQ2.5 / DR4—DQ8 | 30 (17.65) | 1 (0.52) | <0.0001 | 40.93 |
| DR4—DQ2.3 / DRX | 22 (12.94) | 8 (4.17) | 0.004 | 3.42 |
| DRX / DRX (non-risk) | 13 (7.65) | 141 (73.44) | <0.0001 | 0.03 |
DR3—DQ2.5 = DRB1*03:01-DQA1*05:01-DQB1*02:01, DR4—DQ8 = DRB1*04:XX-DQA1*03:01-DQB1*03:02, DR4—DQ2.3 = DRB1*04:XX-DQA1*03:01-DQB1*02:01
n (%) p value Fisher exact test