Table 8. Extended haplotype of class II risk epitopes in type 1 diabetes patients and control subjects.
HLA class II Genotype | Patients (%) (N = 182) | Control subjects (%) (N = 192) | P value | OR | 95% CI |
---|---|---|---|---|---|
DRB Q 70- DQB L26A57 DQA Y11R52R55F61T64I66L69V/L76H129E/K175/ X | 103 (57%) | 48 (25%) | <0.0001 | 3.8 | 2.5–5.9 |
DRB Q 70—DQB L26A57 DQA Y11R52R55F61T64I66L69V/L76H129E/K175/ DRB Q 70—DQB L26A57 DQA Y11R52R55F61T64I66L69V/L76H129E/K175 | 64 (35%) | 3 (2%) | <0.0001 | 34.2 | 10.5–111.2 |
X / X (non-risk) | 15 (8%) | 141 (73%) | <0.0001 | 0.03 | 0.02–0.06 |