Fig 4. miR-124 does not affect neurological function after photothrombosis.
(A-C) Rotating pole test scores of mice subjected to sham surgery or PT surgery and treated either with saline, void NPs, scramble-miR NPs or miR-124 NPs administered intravenously immediately after PT. Results in (A-C) show the performance at 10 rotations of the pole to the left a day before surgery (day -1), 2 days and 14 days after the insult, respectively; data are presented as medians with the 1st and 3rd quartile. (D) Grid test presenting the number of foot faults of the left side paws traversing a 60 cm long grid as indicated in the Methods section. Sham-operated mice and mice subjected to PT of the abovementioned treatment groups were evaluated at days 0, 2, 7 and 14. All data are represented as medians with the 1st and 3rd quartile with 6 to 11 animals per group: sham n = 11, PT saline n = 6, PT void NPs n = 6, PT scramble-miR NPs n = 7, PT miR-124 NPs n = 8. Abbreviations: NPs, nanoparticles; PT, photothrombosis.