Table 1.
Clinical characteristics at time of renal biopsy
| C4d+DSA+ (n=35) |
C4d−DSA+ (n=24) |
Controls (n=15) |
|
|---|---|---|---|
| Age (years)(range) | 41(28.0-48.5) | 36.5 (27.5-46.2) | 39 (30.5-50.5) |
| Gender (M/F) (%) | 20/15 (57/43) | 18/6 (75/25) | 9/6 (60/40) |
| Race (C/AA/H) (%) | 19/15/1 (54/43/3) | 12/12/0 (50/50/0) | 12/3/0 (80/20/0) |
| Donor type | |||
| D/LR/LU (%) | 15/8/12a (43/23/34) | 14/3/7a (58/12/29) | 8/7/0a (53/47/0) |
| HLA compatibility (Incompatible/compatible) | 1/26 | 2/26 | 0.6 |
| HLA mismatches | |||
| A/B/DR≤3 | 16 | 16 | 9 |
| A/B/DR>3 | 19 | 8 | 6 |
| Time between transplant and biopsy (days) | 583 | 410 | 377 |
| Indication for biopsy [n (%)] | |||
| Increased creatinine | 21 (60) | 20 (84) | 10 (66) |
| Proteinuria | 1 (3) | 1 (4) | 1(7) |
| Increased creatinine and proteinuria | 13 (37) | 3 (12) | 3 (20) |
| DGF | 0 | 0 | 1(7) |
| Creatinine (mg/dl) | 4.49 | 5.78 | 4.10 |
| Proteinuria [n (%)] | |||
| Negative | 4 (11) | 2(8) | 5(33) |
| Sub-nephrotic | 25(72) | 20(84) | 8(53) |
| Nephrotic | 4 (11) | 0 | 1(7) |
| Not available | 2 (6) | 2 (8) | 1(7) |
M= male; F= female; C= Caucasian; AA= African-American; H=Hispanic; D=deceased donor; LR=living related donor; LU=living unrelated donor; DGF=delayed graft function.
a
p=0.037.