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. 2018 Feb 28;9(3):330. doi: 10.1038/s41419-017-0023-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The scheme represents the classical view of MFN2 as a positive modulator of ER−mitochondria juxtaposition. In this model, MFN2 on ER membrane engages MFN2 or MFN1 on OMM, mediating the tethering between the two organelles. b The scheme represents the model of MFN2 as a negative modulator of ER−mitochondria juxtaposition. According to this view, MFN2 on both the ER and the OMM interacts with and sequesters still unknown tethering subunits (left), hindering their assembling into a functional tethering complex (represented on the right)