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. 2018 Jan 13;9(3):368–375. doi: 10.1111/1759-7714.12587

Figure 1.

Figure 1

Melatonin could block the survival and proliferation of estrogen receptor‐positive breast cancer cells induced by bisphenol A (BPA). (a) MTT assay was performed to evaluate cell proliferation. Cells were incubated for 96 hours and the value of optical density 490 nm was measured as described in the MTT method. The bars represent the average value and the standard deviation of at least three independent experiments; *P < 0.05. The survival and proliferation of MCF‐ 7 (b) and T47D (c) cells were detected by colony formation assay as described above, the proliferative ability was enhanced by BPA (100 nM) and E2 (10 nM), while this enhancement could be blocked by melatonin (1 nM). The bar graph showed statistical analysis of colony numbers for at least three experiments; *P < 0.05. Ctrl, E2, BPA.