Table 2. Results returned in CSER U-award studies.

Site	Indication-specific findings	Tumor analysis	Actionable secondary or incidental findings	Pharmacogenetic findings	Carrier status	Nonactionable secondary or incidental findings	Other	VUS
1	Yes	Yes	ACMG plus additional	Yes	Yes (opt-out)	No		All tumor VUS; germ-line VUS only related to indication
2	Yes	Select variants associated with chemotherapy recommendations	ACMG plus additional	Select gene–drug pairs	10 conditions	No		VUS related to indication and for medically actionable genes that family analysis would clarify
3	Yes	No	ACMG plus additional	Yes	Yes	Yes	Risk variants for select common complex conditions based on GWAS and red blood cell/platelet antigen typing	VUS related to indication and VUS favor pathogenic regardless of indication
4	Yes	No	ACMG plus additional	No	3 conditions plus OMIM genes for which participating parents are both carriers	No		VUS related to indication
5	Yes	No	Locally determined list of actionable conditions	Yes (opt-in)	Yes (opt-in)	Yes (opt-in), including rare but highly penetrant variants for serious nontreatable conditions	Variants for risk in select common complex conditions based on GWAS (opt-in)	VUS related to indication
6	Yes	Actionable or potentially actionable somatic variants with focus on therapy	ACMG plus additional	No	Yes	No		VUS related to indication
7	Yes	No	ACMG plus additional (opt-in)	No	Carrier status is focus of study	No	Variants in mitochondrial genes	No
8	Yes	Yes	Custom list of 2,000 plus genes		Yes	No		VUS related to indication
9	Yes	Yes	Yes	No	No	No		No

ACMG, American College of Medical Genetics and Genomics; CSER, Clinical Sequencing Exploratory Research Consortium; GWAS, genome-wide association studies; VUS, variants of uncertain significance.

“ACMG” refers to the roster of 56 secondary findings in Green et al.²²