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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Mol Aspects Med. 2017 Sep 1;64:1–17. doi: 10.1016/j.mam.2017.08.002

Figure 6.

Figure 6

MCTR Biosynthesis and Structures. The MCTR biosynthetic pathway is initiated by lipoxygenation of DHA at carbon position 14 leading to 14S-hydro(peroxy)-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid, this is converted by lipoxygenase activity to 13S,14S-epoxy −4Z,7Z,9E,11E,16Z,19Z- docosahexaenoic acid. Conversion of this allylic epoxide is to MCTR1 is catalyzed by either glutathione s-transferase mu4 (GSTM4) and by leukotriene C4 synthase (LTC4S). MCTR1 is converted by gammaglutamyl transferase (GGT) to MCTR2 that in turn is substrate for conversion by dipeptidase (DPEP) to MCTR3.