Table 1.
Schizophrenia Patients (n = 52) |
Healthy Comparison Participants (n = 41) |
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n | % | n | % | Statistic | p | |
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Demographics | ||||||
Gender (Female/Male) | 15/37 | 28.8/71.2 | 6/35 | 14.6/85.4 | χ2(1) = 2.65 | 0.136 |
Cigarette Smoker (Yes/No) | 16/36 | 30.8/69.2 | 5/36 | 12.2/87.8 | χ2(1) = 4.52 | 0.033 |
M | SD | M | SD | Statistic | p | |
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Age (years) | 26.10 | 8/17 | 30.22 | 7.07 | F(1,91) = 6.56 | 0.012 |
Education (years) | 13.10 | 2.19 | 14.44 | 1.98 | F(1,91) = 9.40 | 0.003 |
Parental Education (years) | 14.02 | 3.54 | 15.07 | 2.65 | F(1,91) = 2.52 | 0.116 |
CPZ-Equiv. Dose(mg/day) | 204.17 | 116.26 | ||||
Age of Psychosis Onset (years) | 22.59 | 3.89 | ||||
Cigarettes in Past Week (no.) | 4.60 | 15.36 | 1.71 | 5.08 | F(1,91) = 1.33 | 0.251 |
Symptoms (summary scores) | ||||||
SAPS | 4.17 | 3.55 | ||||
SANS | 8.98 | 4.34 | ||||
Cognition (T-scores)a | ||||||
Working Memory | 43.26 | 15.45 | ||||
Speed of Processing | 32.26 | 12.00 | ||||
Attention/Vigilanceb | 37.39 | 12.29 | ||||
Verbal Learning | 42.41 | 10.16 | ||||
Visual Learning | 38.59 | 11.27 | ||||
Reasoning/Problem Solving | 38.67 | 9.03 | ||||
Social Cognitionb | 41.34 | 12.49 | ||||
MCCB Overall Compositec | 32.81 | 14.42 | ||||
P50 Measures | ||||||
S1 Amplitude (µV) | 2.88 | 1.65 | 3.50 | 1.84 | F(1,91) = 2.93 | 0.090 |
S2 Amplitude (µV) | 1.56 | 1.11 | 1.44 | 1.21 | F(1,91) = 0.26 | 0.612 |
S2/S1 Ratio Score | 0.60 | 0.41 | 0.39 | 0.28 | F(1,91) = 7.87 | 0.006 |
Note. Numbers and percentages of participants are reported for gender and cigarette smoking status, which was analyzed using a Pearson chi-square test. Group means (M) and standard deviations (SD) are reported for age, personal and parental years of education, and number of cigarettes consumed in the past week, which were analyzed using analysis of variance (ANOVA). Group mean (M) and standard deviation (SD) of the schizophrenia patient sample are reported for chlorpromazine (CPZ)-equivalent dosages, age of psychosis onset, total scores on the Scale for the Assessment of Positive Symptoms (SAPS) and on the Scale for the Assessment of Negative Symptoms (SANS), and norm-based T-scores on the MATRICS Consensus Cognitive Battery (MCCB). Mean P50 Stimulus 1 (S1) and Stimulus 2 (S2) amplitudes and S2/S1 Ratios are reported for both groups.
Data were collected from a subset of 39 schizophrenia participants who completed cognitive evaluation.
Data unavailable for 1 participant.
Data unavailable for 2 participants.