Table 3.

Operating Characteristics comparing the three designs using discrete dose logistic responses

	Standardized Dose Level	True Prob. of DLT	Percent Patients at Dose Level			Percent Trials with Dose Level as MTD
			DE	NDE	NS	DE	NDE	NS
True MTD −0.16	−0.125	0.356	36.5	–	–	71.7	–	–
	0	0.45	51	77.71	86.4	27.6	99.3	99.2
	0.2	0.605	10.2	18.08	10.6	0.7	0.7	0.8
	0.4	0.742	1.97	3.546	2.35	0.0	0.0	0.0
	0.6	0.844	0.33	0.599	0.51	0.0	0.0	0.0
	0.8	0.91	0.03	0.06	0.06	0.0	0.0	0.0
	1	0.95	0.003	0.006	0.01	0.0	0.0	0.0
	1.25	0.977	0	–	–	0.0	–	–
Average % DLTs: DE 42.4, NDE 52.3, NS 46.1; % trials w. DLT rate > θ + 0.1: DE 52.3, NDE 83.2, NS 71.5
True MTD 0.52	−0.125	0.03	0	–	–	0.0	–	–
	0	0.05	8.27	8.43	8.3	0.0	0.0	0.0
	0.2	0.111	13.84	14.06	14.7	9.4	9.2	9.2
	0.4	0.229	40.98	41.27	42.9	61.4	60.1	63.6
	0.6	0.414	28.86	28.54	26.6	27.9	26.9	26.3
	0.8	0.627	6.27	6.12	5.8	1.3	1.3	0.9
	1	0.8	1.647	1.58	1.7	0.0	2.5	0.0
	1.25	0.922	0.12	–	–	0.0	–	–
Average % DLTs: DE 28.5, NDE 27.6, NS 28.2; % trials w. DLT rate > θ + 0.1: DE 0.1, NDE 0.0, NS 0.0
True MTD 1.22	−0.125	0.007	0	–	–	0.0	–	–
	0	0.01	6.83	17.98	6.85	0.0	0.0	0.0
	0.2	0.019	3.68	9.68	3.7	0.0	0.0	0.0
	0.4	0.035	4.23	11.14	3.98	0.0	0.0	0.0
	0.6	0.065	5.75	14.59	5.69	0.7	0.6	0.3
	0.8	0.116	11.47	21.1	10.36	7.3	2.8	5.0
	1	0.2	28.14	25.51	69.41	40.9	96.6	94.7
	1.25	0.358	39.91	–	–	51.1	–	–
Average % DLTs: DE 21.9, NDE 5.3, NS 15.6; % trials w. DLT rate > θ + 0.1: DE 0.0, NDE 0.0, NS 0.0